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Staying abreast of new technology and diagnostic as well as treatment options for our patients is a high priority at Baylor Scott & White Heart and Vascular Hospital. Our goal is to develop and be involved in advanced research of the highest integrity that will allow our patients to participate in and benefit from innovative heart and vascular discoveries. Research is the backbone and first step in defining patient care. The 75-plus trials we are currently running are investigating many areas, including an anticoagulant that does not require INR bloodwork, genes and angina, atrial fibrillation, and stenting of the left main coronary artery.

The physicians on our medical staff and clinical staff members have been published in numerous journals and books, on topics ranging from atrial septal defects to congestive heart failure to angiography. Recent articles are included below:

Cardiac Surgery Publications

Efficacy and effectiveness of on- versus off-pump coronary artery bypass grafting: A meta-analysis of mortality and survival.

Filardo G, Hamman BL, da Graca B, Sass DM, Machala NJ, Ismail S, Pollock BD, Collinsworth AW, Grayburn PA.
Despite many studies comparing on- versus off-pump coronary artery bypass graft (CABG), there is no consensus as to whether one of these techniques offers patients better outcomes.

Novel Cardiac Coordinate Modeling System for Three-Dimensional Quantification of Inflow Cannula Malposition of HeartMate II LVADs.

Lima B, Dur O, Chuang J, Chamogeorgakis T, Farrar DJ, Sundareswaran KS, Felius J, Joseph SM, Hall SA, Gonzalez-Stawinski GV.
Optimal function of left ventricular assist devices (LVADs) depends on proper alignment of the inflow cannula (IC). Quantitative guidelines for IC angulation are lacking because of variation in cardiac geometry and difficulty in analyzing three-dimensional (3D) cannula orientation relative to the left ventricle (LV). Based on contrast-enhanced computed tomography images from five normal and five clinically malpositioned IC cases in patients with HeartMate II LVADs, we developed a method for 3D quantification of IC malpositioning. Using Mimics image software (Materialise, Leuven, Belgium), the native heart, major arteries, and LVAD were segmented to create patient-specific 3D models, allowing LV cavity volume and long-axis length to be measured directly. The deviation of the IC was quantified in a cylindrical coordinate system at the IC insertion point relative to the mitral valve and septum, and IC occlusion was assessed by the distance between cannula inlet and the proximal endocardium. Compared with normal cases, patients with malpositioned pumps had shorter LV length (p = 0.03) and reduced pump pocket depth (p = 0.009). Malpositioned pumps may experience greater obstruction by the nearby myocardium. This quantitative 3D modeling tool may help identify different modes of pump malalignment and migration and may facilitate preoperative planning and minimally invasive approaches via virtual LVAD implantation.

Utilization of high donor sequence number grafts in cardiac transplantation.

Squiers JJ, DiMaio JM, Sarcino G, Qin H, Felius J, Chamogeorgakis T, MacHannaford JC, Rafael AE, Kale P, Joseph SM, Hall SA, Gonzalez-Stawinski GV, Lima B.
Donor sequence number (DSN) represents the number of candidates to whom a graft was offered and declined prior to acceptance for transplantation. We sought to investigate the outcomes of patients receiving high DSN grafts. Consecutive isolated adult cardiac transplantations performed at a single-center were reviewed. Recipients were grouped into standard (?75th percentile) DSN and high (>75th percentile) DSN. A previously validated donor risk index was used to quantify the risk associated with donor grafts, and recipient outcomes were assessed. Overall, 254 patients were included: 194 standard DSN (range 1-79) and 60 high DSN (range 82-1723). High DSN grafts were harvested at greater distance (P < .001) with increased ischemia time (P < .001), resulting in a modest increase in donor risk index (1 point median difference, P=. 014). High DSN recipients were less frequently listed as UNOS status 1A (P < .001). Despite a nonsignificant trend toward increased in-hospital/30-day mortality in high DSN recipients, there were no differences in primary graft dysfunction or 1-year survival (high DSN 89% vs standard DSN 88%, P=. 82). After adjustment for risk factors, high DSN was not associated with increased 1-year mortality (hazard ratio 1.18, 95%-CI 0.54-2.58, P=. 68).

Major Adverse Renal and Cardiac Events Following Angiography and Cardiac Surgery.

Tecson KM, Brown D, Choi JW, Feghali G, Gonzalez-Stawinski GV, Hamman BL, Hebeler R, Lander SR, Lima B, Potluri S, Schussler JM, Stoler RC, Velasco C, McCullough PA.
Patients at high risk for developing post-procedural complications may receive iodixanol, an iso-osmolar contrast, during coronary angiography to minimize the risk of renal toxicity. For those who additionally require cardiac surgery, the wait-time between angiography and surgery may be a modifiable factor capable of mitigating poor surgical outcomes; however, there have been inconsistsent reports regarding the optimal wait-time. We sought to determine the effects of wait time between angiogram and cardiac surgery, as well as contrast induced acute injury (CI-AKI) on the development of major adverse renal and cardiac events (MARCE).

Asymptomatic Ascending Aorta Aneurysm with Severe Aortic Regurgitation Caused by Multiple Intimal-Medial Tears Unassociated with Aortic Dissection.

Velasco CE, Hashemi H, Roullard CP, MacHannaford J, Roberts WC.
A 62-year-old man was found to have an asymptomatic ascending aortic aneurysm (6.6?cm) associated with severe aortic regurgitation. Operative resection of the wall of the aneurysm disclosed its cause to be multiple healed intimal-medial tears without dissection involving a previously normal aorta. The concept of an intimal-medial tear unassociated with aortic dissection is a poorly recognized entity and these tears appear to be asymptomatic and after the aortic tearing lead to aneurysmal formation.

Baumgarten H, Squiers JJ, Brinkman BT, Vasquez J. Endovascular Technique for Repair of Descending Thoracic Aortic Aneurysm After Coarctation Operation. The Annals of Thoracic Surgery Feb 2017; 103(2):e167-e169.

Can use of an administrative database improve accuracy of hospital-reported readmission rates?

Edgerton JR, Herbert MA, Hamman BL, Ring WS.
Readmission rates after cardiac surgery are being used as a quality indicator; they are also being collected by Medicare and are tied to reimbursement. Accurate knowledge of readmission rates may be difficult to achieve because patients may be readmitted to different hospitals. In our area, 81 hospitals share administrative claims data; 28 of these hospitals (from 5 different hospital systems) do cardiac surgery and share Society of Thoracic Surgeons (STS) clinical data. We used these 2 sources to compare the readmissions data for accuracy.

Comparison of Clinical Characteristics, Complications, and Outcomes in Recipients Having Heart Transplants <65 Years of Age Versus ?65 Years of Age.

Jamil A, Qin H, Felius J, Saracino G, Rafael AE, MacHannaford JC, Gonzalez-Stawinski GV, Lima B.
Advanced recipient age remains a limiting factor for heart transplant candidacy, with many centers reluctant to transplant older patients. Here, we report our experience with recipients aged ?65 years compared with younger recipients in terms of baseline characteristics, intraoperative and immediate postoperative experiences, and post-transplant morbidity and survival. The main study outcome was primary graft dysfunction (PGD), which has not been widely studied in this population. Donor and recipient data from 255 heart transplantations performed between 2012 and 2016 were reviewed. Seventy (27%) recipients were ?65 years and 185 were younger. The older group had a higher frequency of ischemic cardiomyopathy and more frequently had a previous sternotomy than the younger recipients (all p?<0.007). We found no significant differences in post-transplant morbidity (intensive care unit and hospital stay, pneumonia, infections, reoperation for bleeding, stroke, renal failure, or in-hospital mortality; all p?>0.12). One-year survival was also similar in the 2 groups (p?=?0.88). The incidence of moderate or severe PGD was lower in the older group (6%) than in the younger group (16%; p?=?0.037). Multivariate logistic regression found pretransplant creatinine and donor undersizing by predicted heart mass to be predictors of moderate to severe PGD, whereas recipient age ?65 years was identified as protective against PGD in this cohort. In conclusion, our study showed comparable survival and outcomes in recipients ?65 years of age with otherwise similar nutritional status and body mass composition.

Prospective Assessment of Frailty Using the Fried Criteria in Patients Undergoing Left Ventricular Assist Device Therapy.

Joseph SM, Manghelli JL, Vader JM, Keeney T, Novak EL, Felius J, Martinez SC, Nassif ME, Lima B, Silvestry SC, Rich MW.
Frail patients are more prone to adverse events after cardiac surgery, particularly after implantation of left ventricular assist devices. Thus, frailty assessment may help identify patients unlikely to benefit from left ventricular assist device therapy. The purpose was to establish a suitable measure of frailty in adults with end-stage heart failure. In a prospective cohort of 75 patients (age 58?±?12 years) with end-stage heart failure, we assessed the association between frailty (5-component Fried criteria) and the composite primary outcome of inpatient mortality or prolonged length of stay, as well as extubation status, time on ventilator, discharge status, and long-term mortality. Fried frailty criteria were met in 44 (59%) patients, but there was no association with the primary outcome (p?=?0.10). However, an abridged set of 3 criteria (exhaustion, inactivity, and grip strength) was predictive of the primary outcome (odds ratio 2.9, 95% confidence interval 1.1 to 7.4), and of time to extubation and time to discharge. In patients with advanced heart failure, the 5-component Fried criteria may not be optimally sensitive to clinical differences. In conclusion, an abridged set of 3 frailty criteria was predictive of the primary outcome and several secondary outcomes, and may therefore be a clinically useful tool in this population.

Impact of Accurate 30-Day Status on Operative Mortality: Wanted Dead or Alive, Not Unknown.

Ring WS, Edgerton JR, Herbert M, Prince S, Knoff C, Jenkins KM, Jessen ME, Hamman BL.
Risk-adjusted operative mortality is the most important quality metric in cardiac surgery for determining The Society of Thoracic Surgeons (STS) Composite Score for star ratings. Accurate 30-day status is required to determine STS operative mortality. The goal of this study was to determine the effect of unknown or missing 30-day status on risk-adjusted operative mortality in a regional STS Adult Cardiac Surgery Database cooperative and demonstrate the ability to correct these deficiencies by matching with an administrative database.

Clinical Relevance of Baseline TCP in Transcatheter Aortic Valve Replacement.

Sannino A, Stoler RC, Hebeler RF, Szlerip M, Mack MJ, Grayburn PA.
Significant thrombocytopenia (TCP) commonly occurs in seriously ill patients and after open-heart surgery, possibly as a result of cardiopulmonary bypass, use of intraaortic balloon counterpulsation, sepsis, and post-transfusion purpura. However, even severe TCP has not been clearly linked to a significant worsening in outcomes after surgical aortic valve replacement (SAVR). Transcatheter aortic valve replacement (TAVR) is the standard of care in high-risk and intermediate-risk patients with symptomatic severe aortic stenosis (AS). Current evidence suggests that acquired TCP occurring after TAVR may be due to thienopyridine use and extracorporeal circulatory support, and may be associated with adverse outcomes. However, few data exist regarding clinical outcomes associated with baseline TCP in patients undergoing TAVR. In a single small study, moderate-severe TCP was not associated with mortality, although the study was underpowered. Given that TAVR is most often performed in elderly subjects, many of whom are also frail and have baseline TCP, the aim of this study was to evaluate the effect of baseline TCP on clinical outcomes after TAVR.

HeartMate II Left Ventricular Assist Device Pump Exchange: A Single-Institution Experience.

Shaikh AF, Joseph SM, Lima B, Hall SA, Malyala R, Rafael AE, Gonzalez-Stawinski GV, Chamogeorgakis T.
Left ventricular assist devices (LVADs) have revolutionized the treatment of patients with end-stage heart failure. These devices are replaced when pump complications arise if heart transplant is not possible. We present our experience with HeartMate II (HMII (Thoratec, Plesanton, California, United States)) LVAD pump exchange.

Rational Heart Transplant From a Hepatitis C Donor: New Antiviral Weapons Conquer the Trojan Horse

Gottlieb RL, Sam T, Wada SY, Trotter JF, Asrani SK, Lima B, Joseph SM, Gonzalez-Stawinski GV, Hall SA. Hearts from donors with hepatitis C virus (HCV) are underutilized for orthotopic heart transplantation (HT) owing to post-transplantation risks, including increased recipient mortality and coronary allograft vasculopathy. New highly effective direct-acting antiviral agents (DAAs) that target multiple steps in the HCV replication life cycle could transform cardiac transplant outcomes after donor-derived HCV transmission.

Report From the American Society of Transplantation Conference on Donor Heart Selection in Adult Cardiac Transplantation in the United States.

Kobashigawa J, Khush K, Colvin M, Acker M, Van Bakel A, Eisen H, Naka Y, Patel J, Baran DA, Daun T, Luu M, Olymbios M, Rogers J, Jeevanandam V, Esmailian F, Pagani FD, Lima B, Stehlik J.
Cardiac transplantation remains the only definitive treatment for end-stage heart failure. Transplantation rates are limited by a shortage of donor hearts. This shortage is magnified because many hearts are discarded because of strict selection criteria and concern for regulatory reprimand for less-than-optimal posttransplant outcomes. There is no standardized approach to donor selection despite proposals to liberalize acceptance criteria. A donor heart selection conference was organized to facilitate discussion and generate ideas for future research. Participants debated misconceptions and established agreement on donor and recipient risk factors for donor selection and identified the components necessary for a future donor risk score. With agreement on the most important donor and recipient risk factors, it is anticipated that a consistent approach to donor selection will improve rates of heart transplantation.

Comparison of Outcomes of Operative Therapy for Acute Type A Aortic Dissections Provided at High-Volume Versus Low-Volume Medical Centers in North Texas.

Arsalan M, Squiers JJ, Herbert MA, MacHannaford JC, Chamogeorgakis T, Prince SL, Hamman BL, Knoff C, Moore DO, Harrington KB, DiMaio JM, Mack MJ, Brinkman WT.
Immediate surgery is standard therapy for acute type A aortic dissections (TAAD). Because of its low incidence, many smaller cardiac surgery programs do not routinely perform this procedure because it may negatively affect outcomes. Many high-risk, low-volume (LV) surgical procedures are now preferentially performed in reference centers. We compared the outcomes of surgery for TAAD in high-volume (HV) and LV centers in a single metropolitan area to determine the optimal setting for treatment.

Right atrial thrombus and its causes, complications, and therapy.

Benjamin MM, Afzal A, Chamogeorgakis T, Feghali GA.
A 70-year-old man who presented with dyspnea and intermittent chest pain was found to have a large free-floating right atrial thrombus on two-dimensional echocardiogram. Atriotomy was performed, and an 18-cm-long thrombus was removed from the right atrium and inferior vena cava. Postoperatively, the patient developed cardiogenic shock treated by intravenous vasopressor agents and extracorporeal membrane oxygenation. The postoperative course was also complicated by bilateral pulmonary emboli requiring pulmonary artery thrombectomy. Right atrial thrombus is an underdiagnosed condition with a high mortality rate. The best management modality has not yet been established.

Ambulatory extracorporeal membrane oxygenation with subclavian venoarterial cannulation to increase mobility and recovery in a patient awaiting cardiac transplantation.

Jacob S, MacHannaford JC, Chamogeorgakis T, Gonzalez-Stawinski GV, Felius J, Rafael AE, Malyala RS, Lima B.
Venoarterial extracorporeal membrane oxygenation (ECMO) can provide temporary cardiopulmonary support for patients in hemodynamic extremis or refractory heart failure until more durable therapies-such as cardiac transplantation or a left ventricular assist device-can be safely implemented. Conventional ECMO cannulation strategies commonly employ the femoral artery and vein, constraining the patients to the supine position for the duration of ECMO support. We have recently adopted a modified cannulation approach to promote patient mobility, rehabilitation, and faster recovery and to mitigate complications associated with femoral arterial cannulation, such as limb ischemia and compartment syndrome. This technique involves cannulation of the subclavian artery and vein. The current case report details our recent experience with this approach in a critically ill patient awaiting cardiac transplantation.

One-Year Outcomes of Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease.

O'Hair DP, Bajwa TK, Chetcuti SJ, Deeb GM, Stoler RC, Hebeler RF, Maini B, Mumtaz M, Kleiman NS, Reardon MJ, Li S, Adams DH, Watson DR, Yakubov SJ, Popma JJ, Petrossian G.
Early mortality in patients with ESRD is comparable to previously published data on extreme-risk patients without ESRD, but our data suggest a higher mortality rate at 1 year for ESRD patients, likely due to comorbid conditions. Stroke and major vascular injury are infrequent, and improved valve hemodynamics are maintained at 1 year.

The incidence, risk factors, and outcomes associated with late right-sided heart failure in patients supported with an axial-flow left ventricular assist device.

Rich JD, Gosev I, Patel CB, Joseph S, Katz JN, Eckman PM, Lee S, Sundareswaran K, Kilic A, Bethea B, Soleimani B, Lima B, Uriel N, Kiernan M, Evolving Mechanical Support Research Group (EMERG) Investigators.
Early right-sided heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with increased mortality, but little is known about patients who develop late RHF (LRHF). We evaluated the incidence, risk factors, and clinical impact of LRHF in patients supported by axial-flow LVADs.

Lipoma of the Mitral Valve.

Roberts WC, Grayburn PA, Hamman BL.
Described herein is a 67-year-old morbidly obese man who had a lipoma excised from his posterior mitral leaflet after it was found by echocardiogram. Findings in 6 other previously reported cases are reviewed.

A call for standardized end point definitions regarding outcomes of extracorporeal membrane oxygenation.

Squiers JJ, Lima B, DiMaio JM.

Application of the International Society for Heart and Lung Transplantation (ISHLT) criteria for primary graft dysfunction after cardiac transplantation: outcomes from a high-volume centre†.

Squiers JJ, Saracino G, Chamogeorgakis T, MacHannaford JC, Rafael AE, Gonzalez-Stawinski GV, Hall SA, Lima B.
A standardized definition for primary graft dysfunction (PGD) after cardiac transplantation was recently proposed by the International Society of Heart and Lung Transplantation (ISHLT). We sought to characterize the outcomes associated with and identify risk factors for PGD following cardiac transplantation using these criteria at a high volume centre.

HeartMate II Left Ventricular Assist Device Pump Exchange: A Single-Institution Experience.

Shaikh AF, Joseph SM, Lima B, Hall SA, Malyala R, Rafael AE, Gonzalez-Stawinski GV, Chamogeorgakis T.
Left ventricular assist devices (LVADs) have revolutionized the treatment of patients with end-stage heart failure. These devices are replaced when pump complications arise if heart transplant is not possible. We present our experience with HeartMate II (HMII (Thoratec, Plesanton, California, United States)) LVAD pump exchange.

Using extracorporeal membrane oxygenation support preoperatively and postoperatively as a successful bridge to recovery in a patient with a large infarct-induced ventricular septal defect.

Jacob S, Patel MJ, Lima B, Felius J, Malyala RS, Chamogeorgakis T, MacHannaford JC, Gonzalez-Stawinski GV, Rafael AE.
Rupture of the ventricular septum during acute myocardial infarction usually occurs within the first week. The event is usually followed by low cardiac output, heart failure, and multiorgan failure. Despite the many advances in the nonoperative treatment of heart failure and cardiogenic shock, including the intra-aortic balloon pump and a multitude of new inotropic agents and vasodilators, these do not supplant the need for operative intervention in these critically ill patients. This article describes the successful use of extracorporeal membrane oxygenation support as a bridge to recovery postoperatively in a patient with a large infarct-produced ventricular septal defect.

Comparison of Characteristics of Patients Undergoing Heart Transplantation at the Same Hospital in Two Different Time Periods (1997-2012 and 2013-2015).

Roberts WC, Won VS, Vasudevan A, Kapoor P, Ko JM, Meyer DM, Hall SA, Gonzalez-Stawinski GV.
Heart transplantation (HT) increases at some centers each year and decreases at others. We examined characteristics of patients having HT at the same hospital in 2 different time periods (1997-2012 and 2013-2015) by 2 different surgical groups. We compared certain clinical and morphological finding in 291 patients having HT 1997 to 2012 to finding in 228 other patients having HT from 2013 to 2015.

Impact of donor age on cardiac transplantation outcomes and on cardiac function.

Chamogeorgakis T, Joseph S, Hall S, Gonzalez-Stawinski GV, Saracino G, Rafael A, MacHannaford J, Toumpoulis I, Mendez J, Lima B.
Although the impact of older donors on heart transplant outcomes has been previously published, the survival results are conflicting. We herein analyse the impact of older donors on transplant survival and myocardial function.

Avulsion of Aortic Leaflet During Transcatheter Aortic Valve Replacement

Patankar GR, Grayburn PA, Hebeler RF Jr, Henry AC, , Stoler RC.

How to Do It: The Commando Operation for Reconstruction of the Fibrous Skeleton with Double Valve Replacement.

Lima B, Chamogeorgakis T, MacHannaford JC, Rafael A, Gonzalez-Stawinski GV, Lima Md B.
Infiltrative processes that extend into the intervalvular fibrosa, such as infection or calcification, often mandate a complex reconstructive procedure known as the Commando operation. First described less than 20 years ago, this operation is not widely implemented, with experience limited to a few select centers. This report provides a detailed summary of our approach to this intricate procedure.

Donor Hearts: Time to Look at Them in a Different Light?

Gonzalo V. Gonzalez-Stawinski, MD
In this edition of The Journal of Cardiac Heart Failure, 2 papers aim to inform readers of donor groups that could be considered at the time of cardiac donation in the hope of expanding the stagnant donor pool.

An alternative approach to prescribing sternal precautions after median sternotomy, "Keep Your Move in the Tube".

Adams J, Lotshaw A, Exum E, Campbell M, Spranger CB, Beveridge J, Baker S, McCray S, Bilbrey T, Shock T, Lawrence A, Hamman BL, Schussler JM.
An alternative approach to prescribing sternal precautions after median sternotomy, “Keep Your Move in the Tube”. Proceedings Baylor University Medical Center 2016; 29(1): 97-100.

Development of a Squamous Cell Carcinoma of the Hand and Wrist After Cardiac Transplantation.

Carey S, Jackson WT, Hitchcock MA, Lima B, Hall S. Development of a Squamous Cell Carcinoma of the Hand and Wrist After Cardiac Transplantation. American Journal of Cardiology 2016; 117(11): 1853-1854.

Excess short-term mortality in women after isolated coronary artery bypass graft surgery.

Filardo G, Hamman BL, Pollock BD, da Graca B, Sass DM, Phan TK, Edgerton J, Prince SL, Ring WS. Excess short-term mortality in women after isolated coronary artery bypass graft surgery. Open Heart 2016; 3(1): e000386.

Effectiveness and Safety of the Impella 5.0 as a Bridge to Cardiac Transplantation or Durable Left Ventricular Assist Device.

Lima B, Kale P, Gonzalez-Stawinski GV, Kuiper JJ, Carey S, Hall S. Effectiveness and Safety of the Impella 5.0 as a Bridge to Cardiac Transplantation or Durable Left Ventricular Assist Device. The American Journal of Cardiology 2016; 117(10): 1622-1628.

Invited Commentary: Using “broken hearts” for cardiac transplantation: a risky venture or fruitful endeavor?

Lima B. Invited Commentary: Using “broken hearts” for cardiac transplantation: a risky venture or fruitful endeavor? Proceedings Baylor University Medical Center 2016; 29(1): 74. 75.

The Carpentier-Edwards Perimount Magna mitral valve bioprosthesis: intermediate-term efficacy and durability.

Loor G, Schuster A, Cruz V, Rafael A, Stewart WJ, Diaz J, McCurry K. The Carpentier-Edwards Perimount Magna mitral valve bioprosthesis: intermediate-term efficacy and durability. Journal of Cardiothoracic Surgery 2016; Epub.

Frequency of Massive Cardiac Adiposity (Floating Heart) in the Native Hearts of Patients Having Heart Transplantation at a Single Texas Hospital (2013 to 2015) and Comparison of Various Clinical and Morphologic Variables in the Patients With Massive Versus Nonmassive Cardiac Adiposity.

Roberts WC, Won VS, Vasudevan A, Ko JM, Hall SA, Gonzalez-Stawinski GV. Frequency of Massive Cardiac Adiposity (Floating Heart) in the Native Hearts of Patients Having Heart Transplantation at a Single Texas Hospital (2013 to 2015) and Comparison of Various Clinical and Morphologic Variables in the Patients With Massive Versus Nonmassive Cardiac Adiposity. The American Journal of Cardiology 2016; 117(8): 1375-1380.

Massive Diffuse Calcification of the Ascending Aorta and Minimal Focal Calcification of the Abdominal Aorta in Heterozygous Familial Hypercholesterolemia.

Roberts WC, Won VS, Weissenborn MR, Khalid A, Lima B. Massive Diffuse Calcification of the Ascending Aorta and Minimal Focal Calcification of the Abdominal Aorta in Heterozygous Familial Hypercholesterolemia. American Journal of Cardiology 2016; 117(8): 1381-1385.

Atrophy of the Heart After Insertion of a Left Ventricular Assist Device and Closure of the Aortic Valve.

Roberts WC, Hall SA, Ko JM, McCullough PA, Lima B. Atrophy of the Heart After Insertion of a Left Ventricular Assist Device and Closure of the Aortic Valve. American Journal of Cardiology 2016; 117(5): 878-879.

Mitral Valve Replacement After Failed Mitral Ring Insertion With or Without Leaflet/Chordal Repair for Pure Mitral Regurgitation.

Roberts WC, Moore M, Ko JM, Hamman BL. Mitral Valve Replacement After Failed Mitral Ring Insertion With or Without Leaflet/Chordal Repair for Pure Mitral Regurgitation. The American Journal of Cardiology 2016; 117(11): 1790-1807.

Contemporary extracorporeal membrane oxygenation therapy in adults: Fundamental principles and systematic review of the evidence.

Squiers JJ, Lima B, DiMaio JM. Contemporary extracorporeal membrane oxygenation therapy in adults: Fundamental principles and systematic review of the evidence. The Journal of Thoracic and Cardiovascular Surgery 2016; Epub.

Surgery for acquired cardiac disease: An evolving paradigm with a promising future.

Whitson BA, Lima B. Surgery for acquired cardiac disease: An evolving paradigm with a promising future. The Journal of Thoracic and Cardiovascular Surgery 2016; 151(6): 1466-1469.

Cardiology Publications

Adesina GO, Hall SA, Mendez JC, Joseph SM, Gottlieb RL, Kale PP, Bindra AS. Arrthmogenic Right Ventricular Dysplasia: An Under-recognized Form of Inherited Cardiomyopathy . Reviews in Cardiovascular Medicine 2017; 18(1): 37-43.


Bohm M, Young R, Jhund PS, Solomon SD, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Packer M, McMurray JJV. Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF. European Heart Journal Apr 2017; 38(15): 1132-1143.


Cannon JA, Shen L, Jhund PS, Kristensen SL, Kober L, Chen F, Gong J, Lefkowitz MP, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJV, on behalf of the PARADIGM-HF Investigators and Committees. Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction. European Journal of Heart Failure Jan 2017; 19(1): 129-137.


Carey SA, Bass K, Saracino G, East CA, Felius J, Grayburn PA, Vallabhan RC, Hall SA. Probability of Accurate Heart Failure Diagnosis and the Implications for Hospital Readmissions. The American Journal of Cardiology Apr 2017; 119(7): 1041-1046.


Castro MDM, Cossio A, Velasco C, Osorio L. Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study. PLo S Negl Trop Dis.   2017  Apr 5;11(4). eCollection  2017  Apr.


Chen S, Grayburn PA. Ultrasound-targeted microbubble destruction for cardiac gene delivery . Methods in Molecular Biology Jan 2017; 1521: 205-218.


Dehmer GJ, Holper EM. Does Practice Make Perfect? JACC Cardiovascular Interventions May 2017; 10(9): 928-930.


Desai AS, Vardeny O, Claggett B, McMurray JJ, Packer M, Swedberg K, Rouleau JL, Zile MR, Lefowitz M, Shi V, Solomon SD. Reduced Risk of Hyperkalemia During Treatment of Heart Failure with Mineralocorticoid Receptor Antagonists by Use of Sacubitril/Valsartan Compared with Enalapril: A Secondary Analysis of the PARADIGM-HF Trial . JAMA Cardiology Jan 2017; 2(1): 79-85.


East C, Phan T, Filardo G, Franklin J, Donsky A, Wheelan KR, Kowal RC. Repeat ablation and hospitalization following cryoballoon ablation of atrial fibrillation at a single tertiary medical center. Proceedings Baylor University Medical Center Jan 2017; 30(1): 3-6.


El Chami M, Kowal RC, Soejima K, Ritter P, Duray GZ, Neuzil P, Mont L, Kypta A, Sagi V, Hudnall JH, Stromberg K, Reynolds D . Impact of operator experience and training strategy on procedural outcomes with leadless pacing: Insights from the Micra Transcatheter pacing study. Pacing Clinical Electrophysiology Apr 2017; Epub.


Elbehary S, Szerlip HM, McCullough PA. Potassium Excretion and Outcomes in CKD: is K Intake OK? American Journal of Kidney Diseases Mar 2017; 69(3): 325-327.


Afzal A, Sarmast S, Choi JW, McCullough PA, Schussler JM. Spontaneous Coronary Artery Dissection: A Review of Pathogenesis, Presentations, Treatment, and Outcomes. Reviews in Cardiovascular Medicine 2017; 18(1): 29-36.


Farber AJ, Suarez K, Slicker K, Patel CD, Pope B, Kowal R, Michel JB. Frequency of Troponin Testing in Inpatient Versus Outpatient Settings . The American Journal of Cardiology Apr 2017; 119(8): 1153-1155.


Fendler TJ, Nassif ME, Kennedy KF, Joseph SM, Silvestry SC, Ewald GA, LaRue SJ, Vader JM, Spertus JA, Arnold SV. Global Outcome in Patients With Left Ventricular Assist Devices. The American Journal of Cardiology Apr 2017; 119(7): 1069-1073.


Habib PJ, Joseph SM. Why All the Pushback against Counterpulsation? Cardiology Jun 2017; 138(1): 66-68.


Hall, S. In Heart Failure, Where You Have Been May Be More Important Than Where You Are: A Role for Patient-Reported Outcomes. American Journal of Cardiology Mar 2017; 119(5): 813-815.


Harrison JK, Hughes GC, Reardon MJ, Stoler RC, Grayburn PA, Hebeler R, Liu D, Chang Y, Popma JJ, CoreValve US Clinical Investigators. Balloon Post-Dilation Following Implantation on a Self-Expanding Transcatheter Aortic Valve Bioprosthesis. JACC: Cardiovascular Interventions Jan 2017; 10(2): 168-175.


Howard C, Velasco CE , Roullard CP, Rafael A. Aorto-Right Atrial Fistula After Bentall Repair. Proceedings Baylor University Medical Center 2017; 30(3):301-302.


Howard CE, McCullough PA. Decoding Acute Myocardial Infarction among patients on dialysis. Journal of the American Society of Nephrology May 2017; 28(5): 1337-1339.


Jazi HH, McCullough PA. Fitness and strength in young adulthood and protection from future heart failure. Journal of Public Health and Emergency Mar 2017.


Joseph SM, Rich MW. Targeting Frailty in Heart Failure . Current Treatment Options in Cardiovascular Medicine Apr 2017; 19(4): 1-10.


Joseph SM. LVADs and Contemplations on a Flood . Journal of Cardiac Failure Feb 2017; 23(2): 95.


Ailawadi G, Chang HL, O’Gara PT, O’Sullivan K, Woo YJ, DeRose JJ, Parides MK, Thourani VH, Robichaud S, Gillnov AM, Taddei-Peters WC, Miller MA, Perrault LP, Smith RL, Goldsmith L, Horvath KA, Doud K, Baio K, Gelijns AC, Moskowitz AJ, Begiella E, Alexander JH, Iribarne A. Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network. The Journal of Thoracic and Cardiovascular Surgery Jun 2017; 153(6): 1384-1391.


Karatasakis A, Iwnetu R, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Kandzari DE, Lembo NJ, Patel M, Mahmud E, Lombardi WL, Wyman RM, Grantham JA, Doing AH, Toma C, Choi JW, Uretsky BF, Moses JW, Kirtane AJ, Ali ZA, Parikh M, Karacsonyi J, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. The Impact of Age and Sex on In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention. Journal of Invasive Cardiology Apr 2017; 29(4): 116-122.


Kotecha D, Flather MD, Altman DG, Holmes J, Rosano G, Wikstrand J, Packer M, Coats AJS, Manzano L, Bohm M, van Veldhuisen DJ, Andersson B, Wedel H, von Lueder TG, Rigby AS, Hjalmarson A, Kjekshua J, Cleland JGF, Beta-Blockers in Heart Failure Collaborative Group. Heart Rate and Rhythm and the Benefit of Beta-Blockers in Patients With Heart Failure. Journal of the American College of Cardiology Jun 2017; 69(24): 2885-2896.


McCullough PA, Vasudevan A, Sathyamoorthy M, Schussler JM, Velasco CE, Lopez LR, Swift C, Peterson M, Bennett-Firmin J, Schiffmann R, Bottiglieri T. Urinary 11-Dehydro-Thromboxane B2 and Mortality in Patients with Stable Coronary Artery Disease. The American Journal of Cardiology Apr 2017; 119(7): 972-977.


McCullough PA, Zhang J, Ronco C. Volume expansion and contrast-induced acute kidney injury. The Lancet Apr 2017; 389(10076): 1277-1278.


McCullough PA. How Trialists and Pharmaceutical Sponsors Have Failed Us by Thinking That Acute Heart Failure Is a 48-Hour Illness. American Journal of Cardiology Jun 2017; In press.


McCullough PA. Reply: Vitamin E May Protect Against Contrast-Induced Acute Kidney Injury. Journal of the American College of Cardiology Apr 2017; 69(14): 1878-1879.


McCullough PA, Rios A, Smith B. Dialysis fistulas and heart failure. European Heart Journal Mar 2017; Epub.


Mogensen UM, Kober L, Kristensen SL, Jhund PS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJV. The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF . American Heart Journal Jun 2017; 188(1): 35-41.


Muller DWM, Farivar RS, Jansz P, Bae R, Walters R, Clarke A, Grayburn PA, Stoler RC, Dahle G, Rein KA, Shaw M, Scalia GM, Guerrero M, Pearson P, Kapadia S, Gillinov M, Pichard A, Corso P, Popma J, Chuang M, Blanke P, Leipsic J, Sorajja P. Transcatheter Mitral Valve Replacement for Patients with Symptomatic Mitral Regurgitation . Journal of the American College of Cardiology Jan 2017; 69(4): 381-391.


Nguyen HL, Yarzebski J, Lessard D, Gore JM, McManus DD, Goldberg RJ. Ten-year (2001-2011) trends in the incidence rates and short-term outcomes of early versus late onset cardiogenic shock after hospitalization for acute myocardial infarction. Journal of the American Heart Association Jun 2017; 6(6): e005566.


Arsalan M, Squiers JJ , Filardo G, Pollock B, DiMaio JM , Prava B, Gopal A, Mahoney AC, Brown DL, Mack MJ, Grayburn PA. Effect of Elliptical LV Outflow Tract Geometry on Classification of Aortic Stenosis in a Multidisciplinary Heart Team Setting. JACC: Cardiovascular Imaging . Jan 2017; In press.


O’Hair DP, Bajwa TK, Chetcuti SJ, Deeb GM, Stoler RC, Hebeler RF, Maini B, Mumtaz M, Kleiman NS, Reardon MJ, Li S, Adams DH, Watson DR, Yakubov SJ, Popma JJ, Petrossian G . One-Year Outcomes of Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease. The Annals of Thoracic Surgery May 2017; 103(5): 1392-1398.


Packer M, Armstrong WM, Rothstein JM, Emmett M. Sacubitril-Valsartan in Heart Failure. Annals of Internal Medicine May 2017; 166(9): 681-682.


Packer M, Holcomb R, Abraham WT, Anker S, Dickstein K, Filippatos G, Krum H, Maggioni AP, McMurray JJV, Mebazaa A, O’Conner C, Peacock F, Ponikowski P, Ruschitzka F, van Veldhuisen DJ, Holzmeister J, TRUE-AHF Investigators and Committtees. Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure. European Journal of Heart Failure May 2017; 19(5): 673-681.


Packer M, McMurray JJV, Krum H, Kiowski W, Massie BM, Caspi A, Pratt CM, Petrie MC, DeMets D, Kobrin I, Roux S, Swedberg K, ENABLE Investigators and Committees. Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients with Severe Chronic Heart Failure: Primary Results of the ENABLE Trials . JACC Heart Failure May 2017; 5(5): 317-326.


Packer M, McMurray JJV. Importance of endogenous compensatory vasoactive peptides in broadening the effects of inhibitors of the renin-angiotensis system for the treatment of heart failure. Lancet May 2017; 389(10081): 1831-1840.


Packer M, O’Connor C, McMurray JJ, Wittes J, Abraham WT, Anker SD, Dickstein K, Fillppatos G, Holcomb R, Krum H, Maggioni AP, Mebazzaa A, Peacock WF, Petrie MC, Ponikowski P, Ruschitzka F, van Veldhuisen DJ, Kowarski LS, Schactman M, Holzmeister J, TRUE-AHF Investigators. Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure . New England Journal of Medicine May 2017; 376(20): 1956-1964.


Packer M, Pitt B, Rouleau JL, Swedberg K, DeMets DL, Fisher L. Long-Term Effects of Flosequinan on the Morbidity and Mortality of Patients with Severe Chronic Heart Failure: Primary Results of the PROFILE Trial After 24 Years . JACC: Heart Failure Jun 2017; 5(6): 399-407.


Packer M. Double Vision: Replicating a Trial Showing a Survival Benefit . JACC Heart Failure Mar 2017; 5(3): 232-235.


Packer M. Response by Dr. Packer to the Letter of Dr. Blankfield . Journal of Cardiovascular Pharmacology and Therapeutics Jan 2017; Epub.


Packer M. Response by Packer to Letter Regarding Article, “Development and Evolution of a Hierarchical Clinical Composite End Point for the Evaluation of Drugs and Devices for Acute and Chronic Heart Failure: A 20-Year Perspective”. Circulation Apr 2017; 135(15): e892-e893.


Arsalan M, Walther T, Smith RL, Grayburn PA. Tricuspid regurgitation diagnosis and treatment. European Heart Journal March 2017; 38(9): 634-638.


Packer M. Should recommendations for clinical use be restricted to patients who were enrolled in a pivotal clinical trial? European Journal of Heart Failure Jun 2017; 19(6): 779-781.


Packer M. Tetralogy of Fallow: Four Trials and Tribulations . JACC: Heart Failure Jun 2017; 5(6): 408-410.


Packer M. Let Us Not Forget the Long-term Safety Concerns of Sacubitril/Valsartan-Reply. JAMA Cardiology Mar 2017; Epub.


Piccini JP, Stromberg K, Jackson KP, Laager V, Durray GZ, El-Chami M, Ellis CR, Hummel J, Jones DR, Kowal RC, Narasimhan C, Omar R, Ritter P, Roberts PR, Soejima K, Zhang S, Reynolds D, Micra Transcatheter Pacing Study Group. Long-term outcomes in leadless Micra transcatheter pacemakers with elevated thresholds at implantation: Results from the Micra Transcatheter Pacing System Global Clinical Trial. Heart Rhythm May 2017; 14(5): 685-691.


Prasad A, Sohn A, Morales J, Williams K, Bailey SR, Levin D, McCullough PA, Mehran R, Lopez-Cruz G, Harder J. Contemporary Practice Pattern Related to the Risk of Acute Kidney Injury in the Catherization Laboratory: Results from a Survey of Society of Cardiovascular Angiography and Intervention (SCAI) Cardiologists. Catherization Cardiovascular Interventions Feb 2017; 89(3): 383-392.


Raza FS, Grayburn PA, Choi JW. Use of MitraClip for severe mitral regurgitation in a cardiac transplant patient . Proceedings Baylor University Medical Center Apr 2017; 30 (2): 226-227.


Rich JD, Gosev I, Patel CB, Joseph S, Katz JN, Eckman PM, Lee S, Sundareswaran K, Kilic A, Bethea B, Soleimani B, Lima B, Uriel N, Kiernan M, Evolving Mechanical Support Research Group (EMERG) Investigators. The incidence, risk factors, and outcomes associated with late right-sided heart failure in patients supported with an axial-flow left ventricular assist device. The Journal of Heart and Lung Transplantation Jan 2017; 36(1): 50-58.


Roberts WC, Grayburn PA, Guileyardo JM, Stoler RC. Full Development of Consequences of Congenital Pulmonic Stenosis in Eighty-Four Years . The American Journal of Cardiology Apr 2017; 119(8): 1284-1287.


Roberts WC, Grayburn PA, Hamman BL. Lipoma of the Mitral Valve. The American Journal of Cardiology Apr 2017; 119(7): 1121- 1123.


Roberts WC, Kapoor P, Main ML, Guileyardo JM. Acute Aortic Dissection with Intussusception of the Partition between the True and False Channels Leading to Near Total Aortic Occlusion (True Aortic Stenosis). American Journal of Cardiology Jan 2017; 119(2): 340-344.


Becker TM, Grayburn PA, Roberts WC. Mitral Valve Repair for Pure Mitral Regurgitation Followed Years Later by Mitral Valve Replacement for Mitral Stenosis. American Journal of Cardiology Jul 2017; 120(1): 160-166.


Roberts WC, Sherwood M, Grayburn PA. Two causes for one patient for extremely low voltage on the electrocardiogram. Proceedings Baylor University Medical Center Apr 2017; 30(2): 228-229.


Roberts WC. Good Books Received in Cardiovascular Disease in 2016. The American Journal of Cardiology Feb 2017; S0002-9149(17)30186-30188.


Rogers JD, Sanders P, Piokowski C, Sohail MR, Anand R, Crossen K, Khairallah FS, Kaplon RE, Stromberg K, Kowal RC. In-office insertion of a miniaturized insertable cardiac monitor: Results from the Reveal LINQ In-Office 2 randomized study. Heart Rhythm Feb 2017; 14(2): 218-224.


Sannino A, Schiattarella GG, Toscano E, Gargiulo G, Giugliano G, Galderisi M, Losi MA, Stabile E, Cirillo P, Imbriaco M, Grayburn PA, Trimarco B, Esposito G. Meta-Analysis Effect of Body Mass Index on Outcomes after Transcatheter Aortic Valve Implantation. American Journal of Cardiology Jan 2017; 119(2): 308-316.


Seferovic JP, Claggett B, Seidelmann SB, Seely EW, Packer M, Zile MR, Rouleau JL, Swedberg K, Lefkowitz M, Shi VC, Desai AS, McMurray JJV, Solomon SD. Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial . The Lancet Diabetes & Endocrinology May 2017; 5(5): 333-340.


Sheikh IN, Roberts WC. Relation of left ventricular free wall rupture and/or aneurysm with acute myocardial infarction in patients with aortic stenosis . Proceedings Baylor University Medical Center Apr 2017; 30(2): 161-162.


Singer AJ, Than MP, Smith S, McCullough P, Barrett TW, Birkhahn R, Reed M, Thode HC, Arnold WD, Daniels LB, de Filippi C, Headden G, Peacock WF. Missed myocardial infarctions in ED patients prospectively categorized as low risk by established risk scores . American Journal of Emergency Medicine Jan 2017; Epub.


Solomon SD, Rizkala AR, Gong J, Wang W, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M , Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, Desai AS, Shi VC, Lefkowitz MP, McMurray JJV. Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction: Rationale and Design of the PARAGON-HF Trial. JACC Heart Failure 2017 Jul;5(7):471-482; Epub 2017 Jun 26.


Solomon TR, DeJong S, Bilbrey T, Carbone P , Campbell M, Parker RD, Kira A, Amarante D, Schussler JR, Adams J. Cardiac rehabilitation for a skydiver after aortic valve replacement for pure aortic regurgitation and resection of the ascending aorta complicated by active infective endocarditis and heart block requiring a pacemaker. Proceedings Baylor University Medical Center Apr 2017; 30(2): 234-236.


Tecson KM , Arnold W, Barrett T, Birkhahn R, Daniels LB, DeFilippi C, Headden G, Peacock WF, Reed M, Singer AJ, Schussler JM, Smith S, Than MP, McCullough PA. Interpretation of positive troponin results among patients with and without myocardial infarction. Proceedings Baylor University Medical Center Jan 2017; 30(1): 11-15.


Benjamin MM, Afzal A, Chamogeorgakis T, Feghali GA. Right atrial thrombus and its causes, complications, and therapy. Proceedings Baylor University Medical Center Jan 2017; 30(1): 54-56.


Tecson KM, Panettiere-Kennedy KS, Won JI, Garg P, Olugbode O, McCullough PA. Relation between proprotein convertase subtilisin/kexin type 9 and directly measured low-density lipoprotein cholesterol. Proceedings Baylor University Medical Center Jan 2017; 30(1): 16-20.


Vasudevan A, Bottiglieri T, Tecson KM, Sathyamoorthy M, Schussler JM, Velasco CE, Lopez LR, Swift C, Peterson M, Bennett-Firmin J, Schiffmann R, McCullough PA. Residual thromboxane activity and oxidative stress: influence on mortality in patients with stable coronary artery disease . Coronary Artery Disease 2017 Jun;28(4):287-293.


Vasudevan A, Jazi HH, Won JI, Ball T, Patankar GR, Sarmast SA, Shin HJ, McCullough PA. Personalized treatment of heart failure with biomarker guidance using a novel disease severity score . Proceedings Baylor University Medical Center Apr 2017; 30(2): 139-142.


Vasudevan A, Munkres AG, Bottiglieri T, Won JI, Garg P, McCullough PA. Computation of a cardiac severity score with left-censored biomarkers for patients with heart failure . Pathology and Laboratory Medicine International Feb 2017; 9:15-20.


Vasudevan A, Munkres AG, Shin HJ, Sarmast SA, McCullough PA . Integration of Cardiac Biomarkers into a Disease-Specific Score and Its Relation to Intensity of Medical Therapy . Heart Circ Mar 2017; 1(1): 005.


Vasudevan A, Singer AJ, DeFilippi C, Headeen G, Schussler JM, Daniels LB, Reed M, Than MP, Birkhahn R, Smith SW, Barrett TW, Arnold W, Peacock WF, McCullough PA. Renal Function and Scaled Troponin in Patients Presenting to the Emergency Department with Symptoms of Myocardial Infarction . American Journal of Nephrology Feb 2017; 45: 304-309.


Velasco C, Mateo J, Santos A, Mota-Cobian A, Herranz F, Pellico J, Mota RA, España S, Ruiz-Cabello J. Assessment of regional pulmonary blood flow using 68Ga-DOTA PET . EJNMMI Res.   2017  Dec;7(1):7. Epub  2017  Jan 18.


Velasco CE, Howard C . Trouble on Both Sides: Pulmonary Embolism with Pneumothorax. The American Journal of Medicine May 2017; 130(5): 530-533.


Wilson G, Barkley K, Slicker K, Kowal R, Pope B, Michel J. Overuse of troponin? A comprehensive evaluation of testing in a large hospital system . Journal of Hospital Medicine May 2017; 12(5): 329-331.


Won JI, Zhang J, Tecson KM, McCullough PA. Balancing Low-density Lipoprotein Cholesterol Reduction and Hepatotoxicity with Lomitapide Mesylate and Mipomersen in Patients with Homozygous familial Hypercholesterolemia . Reviews in Cardiovascular Medicine 2017; 18(1): 21-28.


Blackbourne BD, Vasudevan A, Roberts WC. Comparison at Necropsy of Heart Weight in Women Aged 20 to 29 Years With Fatal Trauma of Chemical Intoxication Versus Fatal Natural Cause (A Search for the Normal Adult Heart Weight ). American Journal of Cardiology Mar 2017; 119(5): 808-812.


Zaman JAB, Baykaner T, Clopton P, Swarup V, Kowal RC, Daubert JP, Day JD, Hummel J, Schricker AA, Krummen DE, Mansour M, Tomassoni GF, Wheelan KR, Vishwanathan M, Park S, Wang PJ, Narayan SM, Miller JM. Recurrent Post-Ablation Paroxysmal Atrial Fibrillation Shares Substrates with Persistent Atrial Fibrillation: An 11-Center Study . JACC Clinical Electrophysiology Apr 2017; 3(4): 393-402.


Zhang J, Bottiglieri T, McCullough PA. The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome. Cardiorenal Medicine Feb 2017; 7(2): 104-117.


Zhrebker L , Cherni I , Gross LM , Hinshelwood MM , Reese M , Aldrich J , Guileyardo JM , Roberts WC , Craig D , Von Hoff DD, Mennel RG , Carpten JD . Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies . BMC Cancer Jan 2017; 17(1): 17.


Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA, Hahn RT, Han Y, Hung J, Lang RM, Little SH, Shah DJ Shernan S, Thavendiranathan P, Thomas JD, Weissman NJ. Recommendations for Noninvasive evaluation of native valvular regurgitation: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance. Journal of the American Society of Echocardiography Apr 2017; 30(4): 303-371.


Blanke P, Park JK, Grayburn P , Naoum C, Ong K, Kohli K, Norgaard BL, Webb JG, Popma J, Boshell D, Sorajja P, Muller D, Leipsic J. Left ventricular access point determination for a coaxial approach to the mitral annular landing zone in transcatheter mitral valve replacement. Journal of Cardiovascular Computed Tomography Apr 2017; Epub.


Comparative Efficacy of Transradial Versus Transfemoral Approach for Coronary Angiography and Percutaneous Coronary Intervention

Jeffrey M. Schussler, MD, Anupama Vasudevan, BDS, MPH, PhD, Liana J. von Bose, BA, Jane I. Won, BS, Peter A. McCullough, MD, MPH
Transradial artery (TRA) approach is associated with fewer vascular complications and reduced mortality in patients at high risk compared with transfemoral approach (TFA). The objective of our study was to compare the characteristics and outcomes of patients who had coronary angiography by TRA and TFA over the course of hospital implementation of this approach.

Goal-Directed Heart Failure Care in Patients With Chronic Kidney Disease and End-Stage Renal Disease

Peter A McCullough, MD, MPH, Aasim Afzal, MD, MBA, Parag Kale, MD
Investigators have long recognized that renal function and cardiac performance are integrally linked through hemodynamic, neural, humoral, cell signaling, proteomic, and metabolomic pathways (1). Among risk factors for the development of heart failure (HF), chronic kidney disease (CKD) is the most powerful because it contributes to the three fundamental mechanisms of left ventricular failure: 1) pressure overload; 2) volume overload; and 3) cardiomyopathy (2). When CKD progresses to end-stage renal disease (ESRD), these three mechanisms driving HF become more difficult to control because patients undergoing dialysis have on average higher blood pressures; poor volume control only partially addressed by thrice weekly hemodialysis in most cases; and a well-described form of cardiomyopathy characterized by severe left ventricular hypertrophy, marked cardiac fibrosis, reduced capillary density, and calcific deposits on the mitral and aortic valves (3). None of the goal-directed medical or device therapies proven to reduce HF-related hospitalization and cardiovascular death in the general population with HF have been demonstrated to be effective in patients with ESRD (4).

Advanced technology in interventional cardiology: A roadmap for the future of precision coronary interventions

Chad M. Dugas, MD and Jeffrey M. Schussler, MD, FACC, FSCAI
Improving the treatment of patients with cardiovascular disease as well as the safety of the physicians who care for them can potentially be impacted by several new technologies including high-resolution CT coronary imaging with fractional flow reserve, virtual reality, vascular robotic systems, and three-dimensional printing.

A review of spontaneous closure of ventricular septal defect

Jun Zhang, MD, MS, Jong Mi Ko, BA, Joseph M. Guileyardo, MD, and
William C. Roberts, MD
Spontaneous closure of VSD can be determined through a variety of methods — echocardiography, Doppler color flow imaging, angiography, auscultation, and cardiac catheterization — and can be proven by pathological evidence at necropsy.

Commonalities of Cardiac Rupture (Left Ventricular Free Wall or Ventricular Septum or Papillary Muscle) During Acute Myocardial Infarction Secondary to Atherosclerotic Coronary Artery Disease

William C. Roberts, MD, Kendall H. Burks, Jong Mi Ko, BA, Giovanni Filardo, PhD and Joseph M. Guileyardo, MD
Mortality rates during acute myocardial infarction (AMI) continue to drop, however, cardiac rupture (left ventricular free wall or ventricular septum or papillary muscular or combination) continues to remain relatively common. The aim of this study was to identify commonalities among patients with AMI complicated by cardiac rupture.

High-intensity cardiac rehabilitation training of a commercial pilot who, after percutaneous coronary intervention, wanted to continue participating in a rigorous strength and conditioning program.

Sanjay Shrestha, BS, Jenny Adams, PhD, Anne Lawrence, RN, and Jeffrey M. Schussler, MD
A 64-year-old commercial pilot underwent elective percutaneous coronary intervention, and was then sent to cardiac rehabilitation. He wanted to maintain his rigorous strength and conditioning training and eventually return to being a pilot. A specialized training regimen was designed specifically for his needs, and he was able to resume his life as a commercial pilot.

An alternative approach to prescribing sternal precautions after median sternotomy, "Keep Your Move in the Tube"

Jenny Adams, PhD, Ana Lotshaw, PT, PhD, CCS, Emelia Exum, PT, DPT, Mark Campbell, BSc, MSc, Cathy B. Spranger, DrPH, Jim Beveridge, RN, PCCN, Shawn Baker, PT, DPT, MS, Stephanie McCray, RN, Tim Bilbrey, MBA, Tiffany Shock, BS, Anne Lawrence, RN, Baron L. Hamman, MD, Jeffrey M. Schussler, MD
Traditional sternal precautions, given to sternotomy patients as part of their discharge education, are intended to help prevent sternal wound complications. Our research team performed a series of studies that measured the forces exerted during various common activities and their relationship to the sternum. The alternative approach that we introduce applies standard kinesiological principles and teaches patients how to perform load-bearing movements in a way that avoids excessive stress to the sternum.

Surviving Malignant Hypertrophic Cardiomyopathy with all Major Complications in a Single Patient.

Barry J. Maron, MD, Henry L. Weiner, MD, Martin S. Maron, MD, William C. Roberts, MD
This publication discusses a 38 year old patient that presented with all three major disease complications of hypertrophic cardiomyopathy and survived as a result of effective treatment modalities available for individuals with the disease.

Contemporary Review – Best practice guide for cryoballoon ablation in atrial fibrillation: The compilation experience of more than 3000 procedures.

Wilber Su, MD, FHRS, Robert Kowal, MD, FHRS, Marcin Kowalski, MD, FHRS, Andreas Metzner, MD, FHRS, J. Thomas Svinarich, MD, FHRS, Kevin Wheelan, MD, FHRS, Paul Wang, MD, FHRS
This study reviews existing best practices regarding cryoballoon ablation in atrial fibrillation to create a user's consensus guide, providing insight into safer and more effective outcomes for CB2 ablations.

The Two Extremes of Cardiac Sarcoidosis and the Effect of Prednisone Therapy

Danielle Armstrong, DO, Gonzalo V. Gonzalez-Stawinski, MD, Jong M. Ko, BA, Shelley A. Hall, MD, and William C. Roberts, MD
This article contains the clinical and morphologic findings in two patients who underwent heart transplantation because of severe heart failure as a result of cardiac sarcoidosis.

Surgical Coronary Revascularization Using an Off-Pump, No-Touch Technique

Jeffrey M. Schussler, Theodore T. Theologes, Baron L. Hamman

Screening, Diagnosis, and Management of CAD in Asymptomatic Diabetic Patients*

Peter A. McCullough, Poorya Fazel, James W. Choi.

The Incidence and Outcome of Endothermal Heat-induced Thrombosis after Endovenous Laser Ablation

Katherine Kane, Tammy Fisher, Monica Bennett, William Shutze Jr, Taylor Hicks, Brad Grimsley, Dennis Gable, Greg Pearl, Bert Smith, and William Shutze Sr, Dallas, Texas

Safety and Efficacy of Ixmyelocel-T An Expanded, Autologous Multi-Cellular Therapy, in Dilated Cardiomyopathy

Timothy D. Henry, Jay H. Traverse, Baron L. Hammon, Cara A. East, Brian Bruckner, Ann E. Remmers, David Recker, David A. Bull, Amit N. Patel.

Advanced technology in interventional cardiology: A roadmap for the future of precision coronary interventions

Chad M. Dugas, MD and Jeffrey M. Schussler, MD, FACC, FSCAI
Improving the treatment of patients with cardiovascular disease as well as the safety of the physicians who care for them can potentially be impacted by several new technologies including high-resolution CT coronary imaging with fractional flow reserve, virtual reality, vascular robotic systems, and three-dimensional printing.

Vascular Surgery Publications

Parsa P, Eidt J , Rios A, Gable D, Vasquez J Jr. Case Report: An Innovative Endovascular Technique for Repair of Descending Thoracic Aortic Aneurysm following an Open Coarctation Repair. Annals of Vascular Surgery . 2017 May 4.


Parsa P, Rios A, Cantu K, Eidt J , Gable D, Pearl G. Case Report: A Durable Open Repair Of A Rare Profunda Aneurysm . Annals of Vascular Surgery . 2017 Jun 7.


Patel MR, Calhoon JH, Dehmer GJ, Grantham JA, Maddox TM, Maron DJ, Smith PK. ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS 2017 Appropriate Use Criterial for Coronary Revascularization in Patients with Stable Ischemic Heart Disease: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society of Thoracic Surgeons. Journal of the American College of Cardiology May 2017; 69(17): 2212-2241.


Thompson RW, Dawkins C, Vemuri C, Mulholland MW, Hadzinsky TD, Pearl GJ . Performance Metrics in Professional Baseball Pitchers before and after Surgical Treatment for Neurogenic Thoracic Outlet Syndrome. Annals of Vascular Surgery. 2017 Feb;39:216-227; Epub 2016 Aug 12.


Young A, Kastner L, Vasquez J , Jr.  Novel technique of selective stent deployment in complicated thoracic and aortic aneurysm.   Proceedings Baylor University Medical Center Jul 2017; 30(3): 298-300. 



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