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Soltero Cardiovascular Research Center
Clinical Trials

Heart Failure

DREAM

A Double-Blind, Randomized, Sham-Procedure-Controlled, Parallel-Group Efficacy and Safety Study of Allogeneic Mesenchymal Precursor Cells (rexlemestrocel-L) in Patients With Chronic Heart Failure Due to Left Ventricular Systolic Dysfunction of Either Ischemic or Nonischemic Etiology:
DREAM HF-1.

Primary Investigator: Cara East, MD

For more information regarding this trial, please contact Soltero Cardiovascular Research Center at 214.820.2273

EMPEROR-Preserved

Summary: A Phase III randomized, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10mg compared to placebo, in patients with chronic Heart Failure with preserved Ejection Fraction (HFpEF). Empagliflozin outcome trial in patients with chronic heart failure (EMPEROR-Preserved)

Primary Investigator: Cara East, MD, Peter A. McCullough, MD.

For more information regarding this trial, please contact Soltero Cardiovascular Research Center at 214.820.2273

EMPEROR-Reduced

A phase III randomized, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF). Empagliflozin outcome trial in patients with chronic heart failure (EMPEROR-Reduced)

Primary Investigator: Cara East, MD, Peter A. McCullough, MD.

For more information regarding this trial, please contact Soltero Cardiovascular Research Center at 214.820.2273

PERSPECTIVE

A multi-center, randomized, double-blind, active-controlled study to evaluate the effects of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction.

Primary Investigator: Cara East, MD

For more information regarding this trial, please contact Soltero Cardiovascular Research Center at 214.820.2273

Hypertension

SPYRAL OFF MED

Global Clinical Study of Renal Denervation with the Symplicity Spyral multi-electrode renal denervation system in Patients with uncontrolled Hypertension in the Absence of Antihypertensive medications: SPYRAL Study.

Primary Investigator: James W. Choi, MD Sub-Investigator: Cara East, MD

For more information regarding this trial, please contact Soltero Cardiovascular Research Center at 214.820.2273

Prevention

CLEAR Study

A randomized, double-blind, placebo-controlled study to assess the effects of Bempedoic Acid (ETC-1002) on the occurrence of major cardiovascular events in patients with, or at high risk for, cardiovascular disease who are statin intolerant. (CDA completed)

Primary Investigator: Cara East, MD

For more information regarding this trial, please contact Soltero Cardiovascular Research Center at 214.820.2273


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